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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Pedigree Analysis01:35

Pedigree Analysis

Overview

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Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
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Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Published on: January 19, 2024

Distribution patterns in generalized vitiligo.

R Speeckaert1, N van Geel

  • 1Department of Dermatology, Ghent University Hospital, Ghent, Belgium.

Journal of the European Academy of Dermatology and Venereology : JEADV
|May 9, 2013
PubMed
Summary
This summary is machine-generated.

Vitiligo distribution varies by patient characteristics like age, gender, and autoimmune conditions. Face, acral areas, and extremities are most affected, with specific patterns observed in men versus women.

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Published on: August 11, 2016

Area of Science:

  • Dermatology
  • Clinical Epidemiology

Background:

  • Vitiligo, a common pigmentation disorder affecting 1% of the global population, has an incompletely understood distribution pattern.
  • Investigating vitiligo's distribution is crucial for understanding its pathogenesis and clinical presentation.

Purpose of the Study:

  • To determine if the distribution pattern of generalized vitiligo correlates with clinical characteristics.
  • To identify specific demographic and clinical factors influencing vitiligo lesion localization.

Main Methods:

  • Retrospective observational cohort study involving 700 generalized vitiligo patients.
  • Analysis of lesion distribution based on age, gender, and presence of autoimmune disorders.

Main Results:

  • The face (87%), acral areas (76.3%), and extremities (59.7%) were the most common sites for vitiligo.
  • Significant gender-based differences were noted: women showed higher predilection for joints, hips, trunk, and body folds, while men had more beard and genital area involvement.
  • Younger patients were more prone to lower extremity involvement, older patients to upper extremity involvement. Periocular areas were associated with younger age, perioral areas with older age.
  • Acral areas were more frequently affected in patients with autoimmune disorders, particularly thyroid disease.

Conclusions:

  • Vitiligo distribution exhibits significant variations linked to age, gender, and autoimmune associations.
  • These patterns suggest a combination of factors, including Koebner's phenomenon and specific vulnerabilities related to patient characteristics.
  • Understanding these distribution patterns aids in personalized patient management and research into vitiligo pathogenesis.