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Updated: May 11, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Ongoing adaptive immune responses in the microenvironment of melanoma metastases
Nicolas van Baren1, Pierre G Coulie
1Ludwig Institute for Cancer Research Ltd., Brussels, Belgium. nicolas.vanbaren@bru.licr.org
Abstract:
A large body of evidence supports the idea that the tumor environment is immunosuppressive, notably for T lymphocytes. Yet, in some tumor types, the presence of tumor-infiltrating T cells has favorable prognostic value. In order to better understand the functional value of T cells in human tumors, we focused on cutaneous metastases of melanoma and observed that some of them host ectopic lymphoid structures in which B cell, and possibly T cell, responses take place. This observation is discussed in the context of current views on immunosuppression in tumors.
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