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Bioavailability Enhancement: Drug Solubility Enhancement

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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

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Delivery of poorly soluble compounds by amorphous solid dispersions.

Thomas W Y Lee, Nathan A Boersen, H W Hui

¹School of Pharmacy, The Chinese University of Hong Kong, Room 801E, Lo Kwee-Seong Integrated Biomedical Sciences Building, Shatin, N.T. Hong Kong. albert-chow@cuhk.edu.hk.

Current Pharmaceutical Design

|May 9, 2013

Summary

Amorphous solid dispersions enhance drug dissolution and bioavailability. This review covers their fundamentals, manufacturing, and applications, especially for herbal medicines.

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Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Amorphous solid dispersions (ASDs) are crucial for improving drug solubility and bioavailability.
Decades of research highlight their potential in pharmaceutical formulations.

Purpose of the Study:

To review recent advancements in amorphous solid dispersion technology.
To focus on fundamentals, characterization, formulation, and manufacturing.
To explore ASD applications in herbal drugs and natural products.

Main Methods:

Literature review of amorphous solid dispersion technologies.
Analysis of characterization techniques for ASDs.
Examination of formulation and manufacturing strategies.
Review of case studies in herbal drug formulation.

Main Results:

ASDs offer significant improvements in drug delivery.
New amorphization technologies are emerging.
Growing interest in applying ASDs to natural products.

Conclusions:

Amorphous solid dispersions are a key technology for bioavailability enhancement.
Further research into ASDs for herbal medicines is warranted.