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Updated: May 11, 2026

Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
Delivery of poorly soluble compounds by amorphous solid dispersions.
Thomas W Y Lee, Nathan A Boersen, H W Hui
1School of Pharmacy, The Chinese University of Hong Kong, Room 801E, Lo Kwee-Seong Integrated Biomedical Sciences Building, Shatin, N.T. Hong Kong. albert-chow@cuhk.edu.hk.
Amorphous solid dispersions enhance drug dissolution and bioavailability. This review covers their fundamentals, manufacturing, and applications, especially for herbal medicines.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Amorphous solid dispersions (ASDs) are crucial for improving drug solubility and bioavailability.
- Decades of research highlight their potential in pharmaceutical formulations.
Purpose of the Study:
- To review recent advancements in amorphous solid dispersion technology.
- To focus on fundamentals, characterization, formulation, and manufacturing.
- To explore ASD applications in herbal drugs and natural products.
Main Methods:
- Literature review of amorphous solid dispersion technologies.
- Analysis of characterization techniques for ASDs.
- Examination of formulation and manufacturing strategies.
- Review of case studies in herbal drug formulation.
Main Results:
- ASDs offer significant improvements in drug delivery.
- New amorphization technologies are emerging.
- Growing interest in applying ASDs to natural products.
Conclusions:
- Amorphous solid dispersions are a key technology for bioavailability enhancement.
- Further research into ASDs for herbal medicines is warranted.
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