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Related Experiment Video

Updated: May 11, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

Published on: March 14, 2011

Amnion-derived multipotent progenitor cells support allograft tolerance induction.

K Anam¹, Y Lazdun, P M Davis

¹Department of Regenerative Medicine, Operational and Undersea Medicine Directorate at the Naval Medical Research Center, Silver Spring, MD, USA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons

|May 9, 2013

Summary

Human amnion-derived multipotent progenitor cells (AMPs) co-infused with bone marrow cells promote long-term graft tolerance and macrochimerism in mice, reducing risks associated with traditional transplantation methods.

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Orthotopic Hind Limb Transplantation in the Mouse

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Last Updated: May 11, 2026

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Area of Science:

Immunology
Regenerative Medicine
Transplantation Science

Background:

High-dose bone marrow cells (BMCs) induce tolerance but risk graft-versus-host disease.
Mixed chimerism protocols aim for donor-specific tolerance.

Purpose of the Study:

To investigate if co-infusion of human amnion-derived multipotent progenitor cells (AMPs) with BMCs can induce graft tolerance.
To evaluate the potential of AMPs as a cellular therapeutic for transplantation.

Main Methods:

Mice received skin allografts followed by co-infusion of limited BMCs and AMPs.
Minimal conditioning was used prior to cell co-infusion.
Chimerism, T cell responses, regulatory T cells (Tregs), and allograft survival were assessed.

Main Results:

Co-infusion of AMPs and BMCs induced stable, mixed, multilineage macrochimerism.
Donor-reactive T cells were deleted, and regulatory T cells (CD4(+)CD25(+)Foxp3(+)) expanded.
Long-term allograft survival (>300 days) was achieved with minimal conditioning.

Conclusions:

AMPs, when co-infused with BMCs, facilitate macrochimerism and donor-specific graft tolerance.
AMPs show potential as a pro-tolerogenic cellular therapy for solid organ and hematopoietic stem cell transplantation.