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Concurrent Electroencephalography Recording During Transcranial Alternating Current Stimulation (tACS)
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Short-latency artifacts associated with concurrent TMS-EEG.

Nigel C Rogasch1, Richard H Thomson, Zafiris J Daskalakis

  • 1Monash Alfred Psychiatry Research Centre, Central Clinical School, The Alfred and Monash University, Melbourne, Australia.

Brain Stimulation
|May 9, 2013
PubMed
Summary
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Short-latency artifacts in transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) studies can be minimized. Careful attention to muscle stimulation is crucial for accurately measuring TMS-evoked cortical potentials (TEPs) within 10-12 ms.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Signal Processing

Background:

  • Concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG) is a powerful technique for investigating cortical network properties.
  • Short-latency artifacts (<30 ms) significantly impact the measurement of TMS-evoked cortical potentials (TEPs).

Purpose of the Study:

  • To investigate the origin and recovery dynamics of short-latency TMS-EEG artifacts (<30 ms).
  • To compare artifact profiles under varying experimental conditions, including different TMS devices and stimulation parameters.

Main Methods:

  • EEG data were collected during TMS application to a phantom head and in 12 healthy volunteers.
  • Experiments involved different TMS machines, scalp positions, stimulation intensities, and paired-pulse TMS protocols.
Keywords:
ArtifactElectroencephalographyMuscleTranscranial magnetic stimulation

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  • Artifact recovery times were systematically compared across these conditions.
  • Main Results:

    • TMS artifacts showed distinct profiles depending on the TMS device and pulse shape, recovering within approximately 12 ms in phantom models.
    • In humans, a prominent secondary artifact (5-10 ms peaks) emerged during lateral scalp stimulation, persisting for 25-40 ms.
    • Increased TMS intensity amplified this secondary artifact, particularly over motor and prefrontal cortex.

    Conclusions:

    • The secondary artifact in human participants is likely caused by scalp muscle activation following TMS.
    • Accurate TEPs can be reliably measured as early as 10-12 ms post-TMS.
    • Implementing measures to prevent muscle stimulation is essential for precise TEP recordings.