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High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
Published on: July 29, 2011
Endocardial fibroelastosis in a quarterhorse mare
1Clemson Veterinary Diagnostic Center, Clemson University, Columbia, SC 29229, USA. cushin2@clemson.edu
Journal of Comparative Pathology
|May 9, 2013
Summary
A Quarterhorse mare diagnosed with endocardial fibroelastosis experienced chronic weight loss and lethargy. This rare cardiac condition caused significant heart enlargement and fluid accumulation, leading to the horse's death.
Area of Science:
- Veterinary Pathology
- Cardiovascular Science
Background:
- Endocardial fibroelastosis (EFE) is a rare cardiac disease characterized by thickening of the endocardium.
- This case report details a necropsy examination of a Quarterhorse mare presenting with chronic clinical signs.
Observation:
- The mare exhibited chronic inappetence, weight loss, lethargy, diarrhea, and colic.
- Necropsy revealed a markedly enlarged heart with right atrial dilation, congested mesenteric vessels, ascites, pleural effusion, and pulmonary edema.
Findings:
- Histopathological examination showed diffuse thickening of the left endocardium and mitral valve leaflets.
- Microscopic analysis confirmed the thickening was due to the deposition of fibrous connective tissue and elastin fibers, consistent with endocardial fibroelastosis.
Implications:
- This case highlights the pathological presentation of endocardial fibroelastosis in equine medicine.
- Understanding the gross and microscopic findings is crucial for accurate diagnosis and further research into this cardiac condition.
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