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Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
[Diagnosis and treatment of acute colonic pseudo-obstruction]
Pia Ertberg1, Jesper Vilandt, Birgit Bødker
1Gynækologisk-obstetrisk Afdeling G, Hillerød Hospital, Denmark. pia.ertberg@hvh.regionh.dk
Abstract:
Acute colonic pseudo-obstruction (ACPO), also known as Ogilvie's syndrome, is a clinical condition with acute dilatation of the colon without a provable mechanical cause. Early recognition and treatment of the condition is important in order to improve the outcome. The diagnosis is based on clinical and radiographic findings. Supportive therapy should be the initial management. If no improvement occurs after 24 hours, medical treatment with neostigmine administered i.v. is instituted and repeated if necessary. Colonoscopic decompression is the next step, but if ischaemia or perforation appear surgery should be performed.
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