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Updated: May 11, 2026

Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Does skull shape mediate the relationship between objective features and subjective impressions about the face?
Klára Marečková1, M Mallar Chakravarty, Mei Huang
1Rotman Research Institute, University of Toronto, 3560 Bathurst Street, Toronto, Ontario M6A 2E1, Canada. klara.mareckova@gmail.com
Craniofacial bone structure is key for recognizing male faces. For females, body fat negatively impacts sex recognition accuracy, with bone structure alone not fully explaining facial cues.
Area of Science:
- Anthropology
- Forensic Science
- Human Anatomy
Background:
- Previous research identified facial features for sex recognition, influenced by soft tissue and skull bone structure.
- The role of distinct bone structure in facial sex recognition requires further investigation.
Purpose of the Study:
- To investigate the dissociable influences of craniofacial bone structure on facial sex recognition.
- To explore the mediating role of skull morphology in the relationship between facial features and sex identification accuracy.
Main Methods:
- Utilized magnetic resonance (MR) imaging to analyze skull morphology in a large adolescent sample (n=876).
- Employed mediation analysis with bootstrapping to assess the relationship between skull features, facial features, and sex recognition.
- Estimated body fat using bioimpedance analysis.
Main Results:
- Skull features fully mediated the link between facial features and sex judgments in males.
- In females, skull mediation occurred only after accounting for body fat, which negatively impacted accuracy.
- Body fat showed a slight positive influence on male face sex judgments but a robust negative influence on female faces.
Conclusions:
- Craniofacial bone structure is essential for accurate sex judgments of male faces.
- In females, body fat negatively affects sex recognition accuracy, and bone structure alone does not fully explain the observed facial cues.
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