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Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

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Transmission-blocking interventions eliminate malaria from laboratory populations.

A M Blagborough¹, T S Churcher, L M Upton

¹Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK. andrew.blagborough@imperial.ac.uk

Nature Communications

|May 9, 2013

Summary

Transmission-blocking interventions can eliminate Plasmodium parasites from mosquito and mouse populations. This study shows that these interventions alone can reduce parasite transmission and eradicate the infection in vertebrate populations.

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Area of Science:

Malariology
Parasitology
Infectious Disease Epidemiology

Background:

Transmission-blocking interventions target Plasmodium within the insect host to reduce malaria prevalence.
Previous studies show reduced mosquito infection, but lack direct evidence of reduced vertebrate host infection.

Purpose of the Study:

To assess the impact of a transmission-blocking drug on both insect and host populations over multiple transmission cycles.
To provide the first direct evidence of transmission-blocking interventions reducing infection in vertebrate hosts.

Main Methods:

Population and transmission-based study using Plasmodium berghei and Anopheles stephensi.
Assessed a transmission-blocking intervention inhibiting transmission from vertebrate to insect by 32%.

Main Results:

The intervention reduced the parasite's basic reproduction number by 20%.
Plasmodium was eliminated from mosquito and mouse populations in the model system at low transmission intensities.

Conclusions:

Transmission-blocking interventions alone can eliminate Plasmodium from a vertebrate population.
Findings have significant implications for designing and implementing malaria control strategies.