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Related Experiment Video

Updated: May 11, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Intestinal microcirculatory dysfunction and neonatal necrotizing enterocolitis.

Hong-yi Zhang1, Fang Wang, Jie-xiong Feng

  • 1Department of Pediatric Surgery, Tongji Hospital, Tongji Medical College and Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

Chinese Medical Journal
|May 9, 2013
PubMed
Summary
This summary is machine-generated.

Intestinal ischemia contributes to neonatal necrotizing enterocolitis (NEC) by impairing microcirculation. Understanding this role is crucial for developing new treatments for NEC.

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Last Updated: May 11, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

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Published on: July 28, 2023

Transcutaneous Microcirculatory Imaging in Preterm Neonates
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Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
05:39

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

Area of Science:

  • Neonatalogy
  • Gastroenterology
  • Vascular Biology

Background:

  • Necrotizing enterocolitis (NEC) in neonates often involves coagulation necrosis, suggesting intestinal ischemia as a key factor.
  • Existing research on the role of intestinal ischemia in NEC pathogenesis presents conflicting findings.

Purpose of the Study:

  • To review current literature on intestinal microcirculatory dysfunction in neonatal necrotizing enterocolitis (NEC).
  • To clarify the precise role of intestinal microcirculatory dysfunction in the development of NEC.

Main Methods:

  • Literature search of Medline and PubMed using terms 'intestinal microcirculatory dysfunction' and 'neonatal necrotizing enterocolitis'.
  • Selection of original milestone articles and critical reviews by leading investigators.

Main Results:

  • Neonatal intestinal microvasculature is vulnerable due to immature circulatory regulation.
  • Stress in neonates can trigger endothelial dysfunction, leading to vasoconstriction, inflammation, and barrier disruption.
  • Compromised vasculature reduces intestinal perfusion, potentially causing necrosis.

Conclusions:

  • Intestinal ischemia is a significant factor throughout the course of NEC.
  • Therapeutic agents targeting intestinal ischemia, such as HB-EGF, show promise for NEC treatment.