Related Experiment Video
Updated: May 11, 2026
10:52
Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
Published on: December 17, 2010
[Hypophysitis autoimmune. Case series and literature review]
Guadalupe Pérez1, Paloma Almeda-Valdés, Daniel Cuevas-Ramos
1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Endocrinología y Metabolismo, México, D.F.
Gaceta Medica De Mexico
|May 9, 2013
Summary
Autoimmune hypophysitis, a rare pituitary condition, should be considered alongside pituitary tumors. This study reviews nine cases, detailing their diagnosis, treatment, and outcomes.
Area of Science:
- Endocrinology
- Immunology
- Neurology
Context:
- Autoimmune hypophysitis is a rare inflammatory condition affecting the pituitary gland.
- It often presents as a pituitary tumor, complicating diagnosis.
- Early consideration in differential diagnosis is crucial for appropriate management.
Purpose:
- To describe the clinical, biochemical, and imaging features of autoimmune hypophysitis.
- To present treatment strategies and follow-up outcomes in a series of patients.
- To review the existing literature on this rare pituitary disorder.
Summary:
- This study details nine cases of autoimmune hypophysitis diagnosed at a major medical center between 2000-2012.
- It analyzes clinical presentation, laboratory findings, MRI characteristics, therapeutic interventions, and patient follow-up.
- A comprehensive literature review on autoimmune hypophysitis is also provided.
Impact:
- Highlights the importance of considering autoimmune hypophysitis in pituitary tumor diagnostics.
- Provides valuable data on the presentation and management of this rare condition.
- Aids clinicians in improving diagnostic accuracy and patient outcomes for autoimmune hypophysitis.
Related Concept Videos
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
01:27Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
01:23Hypothyroidism II: Pathophysiology
Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
01:24Graves Disease II: Pathophysiology
Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...
01:29Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
01:12Type I Diabetes I: Introduction
Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...