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Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice
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Moyamoya disease in a primarily white, midwestern US population: increased prevalence of autoimmune disease

Regina S Bower1, Grant W Mallory, Macaulay Nwojo

  • 1Department of Neurosurgery, Mayo Clinic College of Medicine, Rochester, MN, USA.

Stroke
|May 9, 2013
PubMed
Abstract

Insights

This study found a higher prevalence of autoimmune diseases, including type 1 diabetes and thyroid disease, in a Midwestern moyamoya disease patient cohort. These findings suggest a potential autoimmune link in moyamoya pathogenesis.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Autoimmune Diseases

Background:

  • Moyamoya disease is a rare cerebrovascular occlusive condition with unknown pathogenesis.
  • Existing research on moyamoya disease cohorts is predominantly from Asian or ethnically diverse North American populations.

Purpose of the Study:

  • To investigate the clinical characteristics of moyamoya disease in a primarily white, Midwestern US population.
  • To identify potential insights into the pathogenesis of moyamoya disease.

Main Methods:

  • Retrospective analysis of patients with angiographically confirmed moyamoya disease.
  • Comparison of comorbidity, cerebrovascular risk factor, and autoimmune disease prevalence with the general population.

Main Results:

  • The study evaluated 94 moyamoya patients, predominantly female (72.3%) and white (85%).
  • A significantly higher prevalence of autoimmune diseases, including type 1 diabetes mellitus (8.5% vs. 0.4%) and thyroid disease (17.0% vs. 8.0%), was observed compared to the general population.
  • Increased prevalence of hyperlipidemia (27.7% vs. 16.3%) was also noted.

Conclusions:

  • This study highlights a significantly higher prevalence of autoimmune disease in a unique, primarily white, Midwestern moyamoya patient population.
  • The findings support a potential autoimmune component in the pathogenesis of moyamoya disease.
Keywords:
immunologymoyamoyapathogenesisrisk factor

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