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Updated: May 11, 2026
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Rapid Nanoprobe Signal Enhancement by In Situ Gold Nanoparticle Synthesis
Published on: March 7, 2018
Gold-nanopatterned single interleukin-6 sandwich immunoassay chips with zeptomolar detection capability based on
1Department of Applied Chemistry, College of Applied Science, Kyung Hee University, Yongin-si, Gyeonggi-do 446-701, Republic of Korea.
The Analyst
|May 9, 2013
Abstract:
We developed a gold-nanopatterned immunoassay chip for single-molecule detection of interleukin-6 based on evanescent field-enhanced fluorescence imaging. The detection limit (496 zM) means that only four molecules need to be present per spot for detection. The sensitivity of this chip is ~5.4 × 10(4)-fold greater than that of a commercial ELISA for IL-6.
