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Updated: May 11, 2026

EPR Monitored Redox Titration of the Cofactors of Saccharomyces cerevisiae Nar1
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Native Cu(A) redox sites are largely resilient to pH variations within a physiological range

Damián Alvarez-Paggi1, Luciano A Abriata, Daniel H Murgida

  • 1INQUIMAE-CONICET and Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pab. 2, C1428EHA Buenos Aires, Argentina.

Chemical Communications (Cambridge, England)
|May 9, 2013
PubMed
Summary

Engineered CuA centers undergo histidine protonation at physiological pH, unlike native CuA. This suggests native CuA may not regulate proton-coupled electron transfer via histidine protonation.

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