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Related Experiment Video

Updated: May 11, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Des-acyl ghrelin: a metabolically active peptide.

Patric J Delhanty¹, Sebastian J Neggers, Aart J van der Lely

¹Department of Medicine, Erasmus University MC, Rotterdam, The Netherlands.

Endocrine Development

|May 9, 2013

Summary

Unacylated ghrelin (UAG) is emerging as a key hormone, acting as a functional inhibitor of acylated ghrelin (AG). UAG shows potential for treating metabolic disorders like diabetes and obesity.

Area of Science:

Endocrinology
Molecular Biology
Metabolic Research

Background:

Unacylated ghrelin (UAG), previously considered a degradation product of acylated ghrelin (AG), is gaining recognition as a distinct and significant hormone.
UAG is encoded by the preproghrelin gene, alongside AG and obestatin, and exhibits unique biological functions.
Emerging research indicates UAG possesses its own receptor, which can be shared with AG under specific experimental conditions.

Purpose of the Study:

To highlight the emerging role of Unacylated Ghrelin (UAG) as a significant hormone in metabolic regulation.
To explore UAG's potential as a functional inhibitor of Acylated Ghrelin (AG) and its therapeutic implications.
To investigate UAG's impact on glycemic control, particularly in conditions associated with elevated AG/UAG ratios.

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Last Updated: May 11, 2026

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Published on: April 20, 2017

Main Methods:

Review of current scientific literature on preproghrelin gene-encoded peptides.
Analysis of experimental data investigating UAG's interaction with ghrelin receptors.
Examination of studies assessing UAG's effects on ghrelin levels and postprandial glycemia in human subjects.

Main Results:

Unacylated ghrelin (UAG) demonstrates potent functional inhibitory effects on Acylated Ghrelin (AG).
UAG significantly suppresses ghrelin levels in obese human diabetic subjects.
UAG improves postprandial glycemia, especially in individuals with high preprandial AG levels.

Conclusions:

Unacylated ghrelin (UAG) is an important hormone with distinct functions separate from Acylated Ghrelin (AG).
UAG's ability to inhibit ghrelin and improve glycemic control positions it as a promising therapeutic candidate.
UAG and its analogs hold potential for treating metabolic disorders such as diabetes, obesity, and Prader-Willi syndrome.