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Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Mitogens and the Cell Cycle

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mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

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Glucagon-like Receptor Agonists01:24

Glucagon-like Receptor Agonists

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Related Experiment Video

Updated: May 11, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
11:36

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Published on: April 28, 2016

Ghrelin and tumors.

Mauro Papotti1, Eleonora Duregon, Marco Volante

  • 1Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, IT-10043 Orbassano, Turin, Italy. mauro.papotti@unito.it

Endocrine Development
|May 9, 2013
PubMed
Summary

Ghrelin and obestatin, hormones involved in metabolism, are found in various cancers. Their role in tumor growth is complex and may involve metabolic pathways rather than direct proliferation control.

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Ghrelin and obestatin are hormones derived from the same gene, with known roles in physiology and metabolic diseases.
  • Their presence and function in various neoplastic conditions, including neuroendocrine and non-neuroendocrine cancers, have been variably reported.
  • Ghrelin's influence on tumor cell functions like proliferation, apoptosis, and invasiveness has been observed in vitro, but effects can be contradictory.

Purpose of the Study:

  • To investigate the synthesis and secretion of ghrelin and obestatin in neoplastic conditions.
  • To explore the mechanisms by which ghrelin influences tumor cell behavior.
  • To assess the potential of targeting the ghrelin/obestatin axis for cancer therapy.

Main Methods:

  • Review of existing studies on ghrelin and obestatin in cancer.

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  • Analysis of in vitro data on ghrelin's effects on tumor cell lines.
  • Investigation of ghrelin receptor involvement in cancer.

    • Main Results:

    • Ghrelin and obestatin are synthesized and secreted in diverse cancer types.
    • Ghrelin can modulate tumor cell proliferation, apoptosis, and invasiveness, with variable outcomes.
    • Ghrelin's neoplastic effects are often mediated by unidentified receptors, not solely GHSR1a.
    • The role of ghrelin/obestatin axis modulation in cancer is linked to metabolic pathways, not direct proliferation control.

    Conclusions:

    • The ghrelin/obestatin axis is implicated in cancer, but its precise role is complex and context-dependent.
    • Ghrelin's impact on tumors may be more related to metabolic regulation than direct cell proliferation.
    • Targeting this axis for cancer treatment is a future possibility, likely focusing on metabolic pathways, but requires further research for clinical application.