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Klotho and chronic kidney disease.

Ming Chang Hu¹, Makoto Kuro-o, Orson W Moe

¹Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Contributions to Nephrology

|May 9, 2013

Summary

Klotho protein, crucial for antiaging and metabolism, is deficient in chronic kidney disease (CKD). Restoring Klotho may offer therapeutic benefits for CKD complications.

Area of Science:

Endocrinology
Nephrology
Molecular Biology

Background:

Klotho protein exists in membrane-bound and soluble forms, with the soluble form acting as an endocrine factor.
Soluble Klotho plays vital roles in antiaging, metabolism, Wnt signaling inhibition, antioxidation, and hormone regulation.
Chronic kidney disease (CKD) is characterized by Klotho deficiency, impacting its endocrine and renal functions.

Purpose of the Study:

To investigate the role of Klotho protein in chronic kidney disease (CKD).
To explore Klotho's potential as an early biomarker and therapeutic target for CKD.

Main Methods:

Review of clinical and basic studies on Klotho protein in CKD.
Analysis of Klotho's functions in biological fluids and its association with CKD pathogenesis.

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Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Evaluation of potential therapeutic strategies involving Klotho supplementation or upregulation.

Main Results:

CKD is associated with deficiency in both endocrine and renal Klotho.
Klotho deficiency contributes to CKD progression and complications like vascular calcification and cardiac hypertrophy.
Therapeutic interventions targeting Klotho may offer renoprotection and alleviate CKD complications.

Conclusions:

Klotho protein deficiency is a key feature of chronic kidney disease.
Klotho serves as a potential early biomarker for CKD.
Modulating Klotho levels presents a promising therapeutic strategy for managing CKD and its associated complications.