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Related Experiment Video

Updated: May 11, 2026

Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation

Published on: July 16, 2014

Behind the screen: pseudobulbar symptoms after deep brain stimulation.

Florian Amtage1, Johann Lambeck, Sebastian Rutsch

  • 1Department of Neurology, University Medical Center Freiburg, Breisacherstr. 64, Freiburg, 79106, Germany, florian.amtage@uniklinik-freiburg.de.

Acta Neurochirurgica. Supplement
|May 9, 2013
PubMed
Summary

Thalamotomy followed by deep brain stimulation (DBS) treated a patient with essential and Parkinsonian tremor. Electrode dislocation caused side effects, including pathological laughter, triggered by household magnetic fields.

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Area of Science:

  • Neurosurgery
  • Neurology
  • Movement Disorders

Background:

  • Thalamotomy was a historical treatment for tremor syndromes.
  • Deep brain stimulation (DBS) is a current standard for movement disorders.
  • Combining thalamotomy and DBS is uncommon.

Observation:

  • A patient with essential and Parkinsonian tremor underwent left thalamotomy and bilateral subthalamic nucleus DBS.
  • Post-DBS, the patient experienced hemidystonia, pathological laughter/crying, dysarthria, and dysphagia.
  • These symptoms arose from DBS electrode dislocation impinging on the internal capsule.

Findings:

  • Dislocation of subthalamic nucleus DBS electrodes caused significant neurological side effects.
  • Symptoms resolved upon cessation of high-frequency stimulation.

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  • Side effects were re-elicited by magnetic fields from a standby LCD television.

    • Implications:

    • This case highlights the potential for pseudobulbar symptoms and pathological laughter from thalamic DBS electrode misplacement.
    • It underscores the susceptibility of DBS systems to environmental magnetic fields, even from devices in standby mode.
    • Understanding these interactions is crucial for managing DBS patients and preventing unexpected stimulation-related adverse events.