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Updated: May 11, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

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Published on: December 21, 2014

Stem cell transplantation and lung dysfunction.

Imad Y Haddad¹

¹Cardon Children's Medical Center, Department of Pediatrics, Division of Critical Care, Mesa, Arizona, USA. imad.haddad@bannerhealth.com

Current Opinion in Pediatrics

|May 9, 2013

Summary

Lung dysfunction after haematopoietic stem cell transplantation (HSCT) is a serious complication. Recent findings show decreasing incidence and improved outcomes due to better understanding of immune responses and advanced critical care.

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Area of Science:

Hematology
Immunology
Pulmonology

Background:

Lung dysfunction is a critical complication following hematopoietic stem cell transplantation (HSCT).
Idiopathic pneumonia syndrome (IPS) and bronchiolitis obliterans represent a spectrum of post-HSCT lung diseases.
These conditions involve complex innate and adaptive immune responses affecting alveolar and airway epithelium.

Purpose of the Study:

To identify factors influencing the incidence and severity of lung dysfunction post-HSCT.
To inform preventive and therapeutic strategies for lung complications after HSCT.

Main Methods:

Review of recent data on post-HSCT lung diseases.
Analysis of experimental models for IPS and bronchiolitis obliterans.
Evaluation of advances in critical care and management recommendations.

Main Results:

Decreasing incidence and improving outcomes for respiratory failure post-HSCT.
Strong association between acute graft-versus-host disease (GVHD) and IPS.
Bronchiolitis obliterans is a hallmark of chronic GVHD.
Experimental models aid in testing lung injury mitigation strategies.
Advances in critical care, early diagnosis, and ventilatory management improve outcomes.

Conclusions:

Understanding factors contributing to post-HSCT lung injury is crucial.
This knowledge will enhance transplant safety and expand HSCT applicability for complex pediatric cases.