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Updated: May 11, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Acute myocardial infarction: early CT aspects of myocardial microcirculation obstruction after percutaneous coronary

Charles Amanieu1, Ingrid Sanchez, Simona Arion

  • 1Department of Radiology, Louis Pradel Hospital, CREATIS, CNRS UMR 5220, INSERM U1044, Lyon, France.

European Radiology
|May 9, 2013
PubMed
Abstract

Insights

Delayed enhanced multidetector CT (DE-MDCT) accurately predicts myocardial microvascular obstruction (MVO) after percutaneous coronary intervention (PCI). This imaging technique shows promise as a prognostic tool for acute myocardial infarction outcomes.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Medical Diagnostics

Background:

  • Myocardial microvascular obstruction (MVO) is a significant prognostic factor after acute myocardial infarction (MI).
  • Accurate assessment of MVO is crucial for predicting patient outcomes.
  • Current methods for MVO assessment can be time-consuming or limited in availability.

Purpose of the Study:

  • To evaluate the efficacy of delayed enhanced multidetector CT (DE-MDCT) in predicting MVO.
  • To compare DE-MDCT findings with delayed enhanced MRI (DE-MRI) for MVO assessment.
  • To determine the diagnostic accuracy of DE-MDCT immediately following percutaneous coronary intervention (PCI).

Main Methods:

  • Thirty-two acute MI patients undergoing successful PCI were included.
  • DE-MDCT was performed immediately after PCI, followed by DE-MRI within one week.
  • Left ventricle segmentation and analysis of CT relative density and hypoenhanced areas were performed.

Main Results:

  • DE-MDCT demonstrated significantly higher relative density in MVO segments compared to infarcted and healthy segments (P < 0.001).
  • DE-MDCT achieved a sensitivity of 94.3% and specificity of 89.2% for MVO detection using a relative density cutoff of 1.36.
  • Combined analysis of hypo- and hyperenhancement on DE-MDCT yielded high diagnostic accuracy (95.3% sensitivity, 89.3% specificity).

Conclusions:

  • DE-MDCT performed immediately after PCI accurately predicts MVO formation.
  • MDCT analysis of both hypo- and hyperenhanced myocardial areas is feasible.
  • DE-MDCT shows potential as a valuable prognostic tool for acute MI outcomes.

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