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AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study
Haiyan Chu1, Meilin Wang, Dongyan Zhong
1State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing, China; Department of Environmental Genomics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China; Department of Genetic Toxicology, the Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
This meta-analysis found that the adiponectin -11426A > G polymorphism is associated with an increased risk of type 2 diabetes mellitus (T2DM). This genetic variation may contribute to T2DM pathogenesis in European and Asian populations.
Area of Science:
- Genetics
- Metabolic Disorders
- Molecular Biology
Background:
- Adiponectin (AdipoQ) is crucial in diabetes mellitus development and a potential type 2 diabetes mellitus (T2DM) gene.
- Previous studies on adiponectin polymorphisms and T2DM risk have yielded conflicting results.
Purpose of the Study:
- To conduct a meta-analysis assessing the association between five AdipoQ polymorphisms and T2DM risk.
- To provide a more precise estimation of the T2DM risk associated with specific adiponectin gene variations.
Main Methods:
- Meta-analysis of 39 selected papers using fixed and random-effects models.
- Evaluation of association strength using odds ratios (ORs) and 95% confidence intervals (CIs).
- Sensitivity analyses and publication bias assessment using Begg's funnel plots and Egger's test.
Main Results:
- The adiponectin -11426A > G polymorphism showed a significantly increased T2DM risk (OR: 1.15, 95% CI: 1.04-1.27).
- Stratified analyses indicated that -11426A > G, -11391G > A, and -11377C > G polymorphisms increase T2DM risk in Europeans.
- The -11377C > G polymorphism also elevates T2DM risk in Asian populations.
Conclusions:
- The adiponectin -11426A > G polymorphism is a significant contributor to T2DM risk.
- Specific adiponectin gene polymorphisms are associated with T2DM risk in diverse ethnic populations.
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