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Updated: May 11, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
Published on: January 19, 2019
Comparison of simple models of periodic protocols for combined anticancer therapy
Marzena Dołbniak1, Andrzej Swierniak
1Department of Automatic Control, Silesian University of Technology, ul. Akademicka 2A, 44-100 Gliwice, Poland. marzena.dolbniak@polsl.pl
Abstract:
Several simple ordinary differential equation (ODE) models of tumor growth taking into account the development of its vascular network are discussed. Different biological aspects are considered from the simplest model of Hahnfeldt et al. proposed in 1999 to a model which includes drug resistance of cancer cells to chemotherapy. Some of these models can be used in clinical oncology to optimize antiangiogenic and cytostatic drugs delivery so as to ensure maximum efficacy. Simple models of continuous and periodic protocols of combined therapy are implemented. Discussion on the dynamics of the models and their complexity is presented.
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