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Isolation of Viable Multicellular Glands from Tissue of the Carnivorous Plant, Nepenthes
Published on: December 22, 2013
A first new antimalarial pregnane glycoside from Gongronema napalense.
Amey Libman1, Hongjie Zhang, Cuiying Ma
1Program for Collaborative Research in the Pharmaceutical Sciences, M/C 781, Department of Medical Chemistry & Pharmacognosy, College of Pharmacy, the University of Illinois, Chicago, Illinois 60612, USA ; Biology Department, Bradly University, Peoria, IL 61625, USA.
Abstract:
As a part of the UIC-based ICBG project in Laos, plants were collected based on ethnomedical interviews and evaluated for antimalarial activity. A CHCl3 extract from the vine of Gongronema napalense (Wall.) Decne. (Asclepiadaceae) showed promising anti-malarial activity while exhibiting low levels of cytotoxicity and was thus followed up with further fractionation and biological evaluation. Bioassay-guided fractionation led to the isolation of a new steroidal glycoside, gongroneside A, which showed antimalarial activity in vitro with an IC50 value of 1.60 and 1.39 microM against the Plasmodium falciparum D6 and W2 clones, respectively.
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