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BRAF V600E-Negative Hairy Cell Leukaemia
Stephen E Langabeer1, David O'Brien, Anthony M McElligott
1Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James's Hospital, Dublin 8, Ireland.
Case Reports in Hematology
|May 9, 2013
Abstract:
Since the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease. A case of hairy cell leukemia is documented with a classical clinical, morphological, immunophenotypic, and cytochemical profile in which the BRAF V600E was not detected. The diagnostic and therapeutic implications are discussed.
