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Updated: May 11, 2026

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Published on: May 31, 2021
Serum tryptase concentrations in beekeepers with and without Hymenoptera venom allergy
F Carballada1, M Alonso, L Vizcaino
1Department of Allergy, Hospital Lucus Augusti, Lugo, Spain.
Background:
Increased tryptase concentrations are a risk marker for the severity of reactions to Hymenoptera stings or venom immunotherapy
Objective:
To investigate serum tryptase concentrations in beekeepers with and without Hymenoptera venom allergy (HVA).
Methods:
Serum tryptase concentrations were measured in adult patients with HVA (n = 91, 37 of whom were beekeepers), beekeepers without HVA (n = 152), and control individuals from the general adult population (n = 246).
Results:
Multivariate analyses revealed that serum tryptase levels were positively associated with beekeeping activities (P < .001) and HVA (P < .001). Tryptase levels were also positively associated with age (P < .001) and male'sex (P = .02), and negatively associated with alcoho consumption (P = .002).
Conclusions:
Beekeeping and HVA are independently associated with increased concentrations of serum tryptase.
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