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Related Concept Videos

Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

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Tumor Progression

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Skin Cancer

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Development of the Lymphatic System

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Related Experiment Videos

Carcinoma developing in a branchial cyst.

Dragana Tegeltija1, Aleksandra Lovrenski, Milana Panjković

  • 1Department for Pathology, Faculty of Medicine, University of Novi Sad, Serbia. tegeltijadragana@sbb.rs

Medicinski Pregled
|May 10, 2013
PubMed
Summary

Branchiogenic carcinoma, a rare malignancy arising from branchial cleft cysts, was diagnosed in a 55-year-old male. Histological examination confirmed invasive squamous carcinoma, necessitating radical neck dissection and radiotherapy.

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Area of Science:

  • Oncology
  • Pathology
  • Head and Neck Surgery

Background:

  • Malignant transformation of branchial cleft cysts into branchiogenic carcinoma is exceptionally rare.
  • Branchiogenic carcinoma is considered a distinct clinicopathological entity.

Observation:

  • A 55-year-old male presented with a neck mass, diagnosed as a cystic tumor.
  • Histopathology revealed squamous epithelium transitioning from normal to atypical, in situ carcinoma, and finally, poorly differentiated invasive squamous carcinoma.
  • The tumor wall contained lymphoid tissue with germinal centers.

Findings:

  • Radical neck dissection was performed following a suspected branchiogenic carcinoma diagnosis.
  • Post-dissection analysis of surrounding tissues and lymph nodes showed no tumor elements.
  • The patient underwent radiotherapy as part of his treatment plan.

Implications:

  • Definitive diagnosis of branchiogenic carcinoma relies heavily on histological findings.
  • A five-year follow-up is crucial to monitor for potential cervical metastasis.
  • This case highlights the importance of thorough histopathological evaluation for rare neck malignancies.