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Related Experiment Videos

"Structural factor" in primary and secondary hypertension.

B Folkow1

  • 1Department of Physiology, University of Göteborg, Sweden.

Hypertension (Dallas, Tex. : 1979)
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

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The structural factor, characterized by increased resistance in blood vessels, significantly influences primary hypertension. Effective antihypertensive therapy should target this structural resetting, though underlying regulatory mechanisms remain unclear.

Area of Science:

  • Cardiovascular Physiology
  • Hypertension Research
  • Vascular Biology

Background:

  • The
  • structural factor
  • plays a crucial role in the hemodynamics of primary hypertension.
  • Previous research highlighted its influence, particularly the
  • structural upward resetting
  • of systemic resistance vessels.

Purpose of the Study:

  • To review the history and influence of the structural factor in primary hypertension.
  • To outline the structural changes in resistance vessels in hypertension.
  • To discuss implications for antihypertensive therapy and the regulation of blood pressure.

Main Methods:

  • Review of historical research on the structural factor in hypertension.

Related Experiment Videos

  • Hemodynamic studies in humans and quantitative studies in rat models of hypertension.
  • Analysis of structural changes in systemic resistance vessels, including wall/lumen ratio and media hypertrophy.

    • Main Results:

    • Demonstrated
    • structural upward resetting
    • of systemic resistance vessels in human primary hypertension.
    • Confirmed rapid increases in precapillary resistance and wall/lumen ratio due to media hypertrophy in both primary and renal hypertension in rats.
    • Evidence suggests the structural factor may be genetically influenced.

    Conclusions:

    • The structural factor, specifically upward resetting of resistance vessels, is a key determinant of hypertension.
    • Antihypertensive strategies should target this structural resetting.
    • The persistence of normotension in most individuals suggests potent, yet poorly understood, negative feedback mechanisms.