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Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

Reticular Dermis

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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Layers of the Epidermis

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Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...

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Related Experiment Video

Updated: May 11, 2026

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding

Published on: August 22, 2016

Exploring the dermal "template effect" and its structure.

Yuzhi Jiang¹, Shuliang Lu

¹Shanghai Burns Institute, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200025, People's Republic of China. yuzhi.jiang@hotmail.com

Molecular Biology Reports

|May 10, 2013

Summary

This summary is machine-generated.

Understanding dermal tissue

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Last Updated: May 11, 2026

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Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

Published on: February 26, 2015

Area of Science:

Biomedical Engineering
Dermatology
Regenerative Medicine

Background:

Scar formation after surgery is a significant clinical challenge.
Dermal tissue integrity and its three-dimensional (3-D) structure are crucial for skin regeneration.
Disruption of dermal structure impairs cell function, leading to scarring.

Purpose of the Study:

To investigate the unclear mesoscopic structure of dermal tissues.
To explore the formation mechanisms of dermal tissue structures.
To understand how 3-D dermal structures influence cell behavior and wound healing.

Main Methods:

Utilizing phase-contrast micro-tomography with synchrotron radiation.
Analyzing the mesoscopic structural organization of dermal tissues.
Correlating structural findings with cell function and regeneration processes.

Main Results:

The mesoscopic structure of dermal tissues remains largely uncharacterized.
Phase-contrast micro-tomography with synchrotron radiation shows promise for visualizing these structures.
This technique may reveal new insights into dermal tissue formation and regeneration.

Conclusions:

Elucidating the 3-D dermal structure is key to understanding scar formation.
Advanced imaging techniques like synchrotron-based micro-tomography are essential for this research.
This work opens new avenues for skin tissue engineering and improved wound healing strategies.