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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes

H-S Lee1, T Briese2, C Winkler3,4

  • 1Pediatric Epidemiology Center, Department of Pediatrics, University of South Florida, Tampa, FL, USA.

Diabetologia
|May 10, 2013
PubMed

Insights

This study investigated if viruses trigger rapid-onset type 1 diabetes in children. Researchers found no increased viral presence or infection history in children with rapid-onset diabetes, suggesting viruses may not be the primary cause.

Area of Science:

  • Virology
  • Immunology
  • Pediatrics

Background:

  • Viruses are suspected triggers for autoimmune (type 1) diabetes.
  • Investigating rapid-onset type 1 diabetes may reveal specific causative viruses.

Purpose of the Study:

  • To determine if viral infections precede rapid-onset type 1 diabetes in children.
  • To identify potential viral agents involved in the pathogenesis of autoimmune diabetes.

Main Methods:

  • Next-generation sequencing used to detect viruses in plasma samples.
  • Examined infection and fever history in children from The Environmental Determinants of Diabetes in the Young (TEDDY) study.
  • Compared rapid-onset type 1 diabetes cases with matched islet-autoantibody-negative controls.

Main Results:

  • No significant difference in viral detection rates between rapid-onset type 1 diabetes patients and controls.
  • Similar infection histories reported in both groups.
  • Fewer fever episodes noted in children with rapid-onset type 1 diabetes.

Conclusions:

  • The study findings do not support the hypothesis of viral infections (viraemia) around seroconversion in young children with rapid-onset type 1 diabetes.
  • Current evidence does not link viral exposure to the rapid development of type 1 diabetes in the studied cohort.
Abstract

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