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Updated: May 11, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
A tale of metabolites: the cross-talk between chromatin and energy metabolism
Barbara Martinez-Pastor1, Claudia Cosentino, Raul Mostoslavsky
1The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Abstract:
Mitochondrial metabolism influences histone and DNA modifications by retrograde signaling and activation of transcriptional programs. Considering the high number of putative sites for acetylation and methylation in chromatin, we propose in this perspective article that epigenetic modifications might impinge on cellular metabolism by affecting the pool of acetyl-CoA and S-adenosylmethionine.
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