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Updated: May 11, 2026
Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics (DCAF)
Published on: September 17, 2019
Protection by immunoglobulin dual-affinity retargeting antibodies against dengue virus
James D Brien1, Soila Sukupolvi-Petty, Katherine L Williams
1Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Abstract:
Dengue viruses are the most common arthropod-transmitted viral infection, with an estimated 390 million human infections annually and ∼3.6 billion people at risk. Currently, there are no approved vaccines or therapeutics available to control the global dengue virus disease burden. In this study, we demonstrate the binding, neutralizing activity, and therapeutic capacity of a novel bispecific dual-affinity retargeting molecule (DART) that limits infection of all four serotypes of dengue virus.
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