Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

Modern Molecular Taxonomy

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Deep learning in tumour genomics: from multi-omics integration to precision oncology.

Open biology·2026

Same author

Responsible Use of Large Language Models in Microbial Genomics and Bioinformatics: A Life-Science Framework for Reliability, Reproducibility, and Risk-Aware Interpretation.

Life (Basel, Switzerland)·2026

Same author

The Nutri-Exposome Intelligence Framework: Integrating Multi-Omics, Machine Learning, and Digital Nutrition for Precision Chronic Disease Prevention.

Nutrients·2026

Same author

Nonocclusive Mesenteric Ischemia in Cardiogenic Shock: Mechanisms of Splanchnic Hypoperfusion and Strategies for Early Detection.

Cardiology in review·2026

Same author

Mechanistic Systems Biology of High-Salinity Fermented Seafood: Multi-Omics Integration for Microbial Safety and Quality Prediction.

Biology·2026

Same author

The Computational Revolution in Natural Product Research: A Data-Driven Roadmap for Next-Generation Drug Development.

Biology·2026

Search research articles

Related Experiment Video

Updated: May 11, 2026

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Published on: September 27, 2018

MabsBase: a Mycobacterium abscessus genome and annotation database.

Hamed Heydari¹, Wei Yee Wee, Naline Lokanathan

¹Dental Research and Training Unit, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.

|May 10, 2013

Summary

Mycobacterium abscessus infections are diverse and not fully understood. A new database, MabsBase, offers genomic data and tools to advance research on this rapidly growing non-tuberculous mycobacterium.

More Related Videos

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Published on: October 25, 2024

Preparation of Agar Bead Embedded Mycobacterium abscessus to Inoculate Immunocompetent Mice Intratracheally

Preparation of Agar Bead Embedded Mycobacterium abscessus to Inoculate Immunocompetent Mice Intratracheally

Published on: April 25, 2025

Related Experiment Videos

Last Updated: May 11, 2026

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Identification of Virulence Markers of Mycobacterium abscessus for Intracellular Replication in Phagocytes

Published on: September 27, 2018

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Assay Development for High-Throughput Drug Screening Against Mycobacteria

Published on: October 25, 2024

Preparation of Agar Bead Embedded Mycobacterium abscessus to Inoculate Immunocompetent Mice Intratracheally

Preparation of Agar Bead Embedded Mycobacterium abscessus to Inoculate Immunocompetent Mice Intratracheally

Published on: April 25, 2025

Area of Science:

Microbiology
Genomics
Bioinformatics

Background:

Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium implicated in various human infections.
The taxonomy, phylogeny, and pathogenicity of M. abscessus require further elucidation.
Understanding M. abscessus is crucial for effective clinical management.

Purpose of the Study:

To introduce MabsBase, a comprehensive database for Mycobacterium abscessus research.
To provide access to whole-genome sequences and computational resources for M. abscessus strains.
To support the scientific community in studying M. abscessus genomics and pathogenicity.

Main Methods:

Development of a user-friendly database (MabsBase).
Inclusion of whole-genome sequences of newly discovered M. abscessus strains.
Integration of resources for genome annotation and computational predictions.

Main Results:

MabsBase provides accessible whole-genome data for M. abscessus.
The database facilitates comparative genomic analysis.
Resources for annotation and prediction are available to researchers.

Conclusions:

MabsBase serves as a valuable resource for the M. abscessus research community.
Genomic insights from MabsBase can improve understanding of M. abscessus taxonomy and pathogenicity.
The database supports advancements in managing M. abscessus infections.