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Changes in the circadian rhythm in patients with primary glaucoma
Huaizhou Wang1, Ye Zhang, Jianming Ding
1Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Vision Science Key Lab, Beijing, China.
Plos One
|May 10, 2013
Summary
Glaucoma patients, including primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG), experience significantly more sleep disturbances than healthy individuals. The prevalence of sleep disorders increases with age and is more pronounced in PACG patients.
Area of Science:
- Ophthalmology
- Sleep Medicine
Background:
- Glaucoma is a leading cause of irreversible blindness.
- Sleep quality is crucial for overall health and well-being.
- The impact of glaucoma on sleep quality remains incompletely understood.
Purpose of the Study:
- To investigate whether glaucoma affects sleep quality.
- To compare sleep quality between primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) patients and healthy controls.
- To assess the influence of age, intraocular pressure (IOP), and visual field (VF) impairment on sleep disturbances in glaucoma patients.
Main Methods:
- Utilized the Pittsburgh Sleep Quality Index (PSQI) questionnaire to assess sleep quality.
- Compared sleep quality in 92 POAG patients, 48 PACG patients, and 199 healthy controls.
- Analyzed sleep disturbances (PSQI score >7) across different age groups and correlated them with IOP and VF impairment in the POAG group.
Main Results:
- The prevalence of sleep disturbances was significantly higher in both POAG and PACG groups compared to controls.
- Sleep quality declined with age in control and POAG groups (P<0.05).
- PACG patients aged 61-80 exhibited a higher prevalence of sleep disturbances than POAG patients in the same age bracket.
Conclusions:
- Glaucoma, encompassing POAG and PACG, is associated with a higher prevalence of sleep disorders compared to healthy individuals.
- Older PACG patients (61-80 years) appear to experience more severe sleep disturbances than their POAG counterparts.
- No significant correlation was found between sleep disorders and VF impairment or diurnal IOP variations in POAG patients.
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