Related Experiment Video
Updated: May 11, 2026

An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
Published on: April 4, 2025
Simulation of incomplete obstructive uropathy in rats by injecting an artificial calculus into the bladder
D A Sosnin1, V V Novochadov, O V Ostrovsky
1Volgograd State Medical University, Russia. dasosnin@yandex.ru
Abstract:
Incomplete varying obstruction of the urinary tract was reproduced by injecting artificial stomatological material into the rat bladder. Inflammatory changes and nephrosclerosis were detected in the renal tissue on days 14 and 21 of the experiment. Urinary concentration of total protein and activity of γ-glutamylaminotransferase increased. A direct positive correlation between the volume percentage of connective tissue and activities of the renal enzymes in the urine was detected.
Related Concept Videos
Urinary Tract Calculi VI: Surgical Management
Urinary Tract Calculi III: Medical Management
Urinary Tract Calculi V: Nursing Management
Imaging Studies VI: Voiding Cystourethrography and Cystography
