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Updated: May 11, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
[Eosinophilic esophagitis: an underevaluated condition. Our experience]
M J Ruiz Catena1, M Díaz Diñeiro, F Ibáñez Cerrato
1Servicio de Cirugía Pediátrica, Unidad de Gestión de Cirugía Pediátrica, Hospital Materno-infantil, Hospital Regional Universitario Carlos Haya, Málaga. manueljessr@gmail.com
Summary
Eosinophilic esophagitis (EE) is a primary esophageal disease presenting with dysphagia and food impaction. Diagnosis requires clinical, endoscopic, and pathological findings, including over 15 eosinophils per high-power field in biopsies.
Area of Science:
- Gastroenterology
- Allergy and Immunology
- Pediatric Medicine
Context:
- Eosinophilic esophagitis (EE) is an emerging allergic inflammatory disease of the esophagus.
- Food impaction is a common emergency presentation in children with EE.
- This review highlights diagnostic challenges and clinical experience with EE.
Purpose:
- To review the epidemiology, pathophysiology, diagnosis, and management of EE.
- To present four pediatric cases of EE diagnosed after emergency food impaction.
- To improve diagnostic suspicion for this condition.
Summary:
- Four pediatric patients (ages 7-11) with EE presented with food impaction and a history of dysphagia and allergies.
- Endoscopic findings were nonspecific, but biopsies revealed eosinophilic infiltration (>15 eosinophils/HPF).
- EE is characterized by esophageal dysfunction symptoms, eosinophilic infiltration on biopsy, and exclusion of GERD.
Impact:
- This study emphasizes the importance of considering EE in pediatric patients with dysphagia and food impaction.
- Accurate diagnosis relies on integrated clinical, endoscopic, and histopathological evaluation.
- Dietary management, avoiding specific food allergens, is a primary treatment strategy.
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