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Supplementation with selenium-enriched yeast attenuates brain metastatic growth
Jagoda K Wrobel1, Melissa J Seelbach, Lei Chen
1Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33136, USA.
Nutrition and Cancer
|May 11, 2013
Summary
Dietary selenium (Se) compounds impact brain metastasis. Yeast-derived organic selenium (Se-Yeast) and sodium selenite (Se-S) improved survival and reduced tumor growth in a mouse model, suggesting Se-Yeast
Area of Science:
- Oncology
- Nutrition Science
- Cancer Metastasis Research
Background:
- Cancer metastasis is the primary cause of cancer-related mortality.
- Dietary factors, including selenium (Se), may influence metastasis development.
- Understanding the impact of different selenium compounds on brain metastasis is crucial.
Purpose of the Study:
- To compare the effects of various dietary selenium compounds on brain metastasis.
- To investigate the efficacy of sodium selenite (Se-S), seleno-1-methionine (Se-Meth), and yeast-derived selenium (Se-Yeast) in a mouse model.
- To evaluate the impact of selenium supplementation on survival and tumor growth in brain metastatic disease.
Main Methods:
- Mice were fed diets supplemented with Se-S, Se-Meth, Se-Yeast, or a control diet for 20 weeks.
- Following the feeding period, mice were injected with luciferase-tagged K1735 melanoma cells into the brain vasculature.
- Brain metastatic tumor development was monitored for 2 weeks using bioluminescence imaging.
Main Results:
- Mice fed Se-Yeast or Se-S enriched diets exhibited increased survival rates compared to control groups.
- Se-Yeast supplementation significantly reduced the growth of brain metastatic tumors.
- The study demonstrated distinct effects of different selenium chemical forms on brain metastasis dynamics.
Conclusions:
- Dietary selenium compounds differentially affect brain metastasis development.
- Organic selenium, specifically Se-Yeast, shows potential as a therapeutic agent for suppressing brain metastatic disease.
- Further research into selenium's role in cancer metastasis is warranted.
