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Related Concept Videos

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...

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Related Experiment Video

Updated: May 11, 2026

Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration
10:22

Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration

Published on: June 25, 2015

[Nuclear transfer and reprogramming in fish].

Xue-Geng Wang1, Zuo-Yan Zhu, Yong-Hua Sun

  • 1College of Life Sciences, Peking University, Beijing, China. wangxuegeng@pku.edu.cn

Yi Chuan = Hereditas
|May 11, 2013
PubMed
Summary
This summary is machine-generated.

Fish nuclear transfer, a key animal cloning technique, has advanced significantly. Understanding epigenetic reprogramming in zebrafish nuclear transfer is crucial for improving cloning success rates.

Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Genetics

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