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Updated: May 11, 2026

Correlative Optical Spectroscopy and Mass Spectrometry Imaging Methodology to Visualise Drug Distribution in a Soft Tissue Section
Published on: June 20, 2025
Photoelectron spectroscopy of non-steroidal anti-inflammatory drugs
Igor Novak1, Leo Klasinc, Delano P Chong
1Charles Sturt University, POB 883, Orange, NSW 2800, Australia. inovak@csu.edu.au
Abstract:
The electronic structures of eight non-steroidal anti-inflammatory drugs (NSAIDs) had been studied by UV photoelectron spectroscopy (UPS) and high-level Green's function (GF) calculations. Our UPS data show that the electronic structure influences the measured biological activity of NSAID, but that it is not the dominating factor. The role of electronic structure needs to be considered in conjunction with other factors like steric properties of the COX active site and orientation of relevant residues in the same site.
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