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[Risk factors of predicting residual disease in women with stage I a1 squamous cervical carcinoma after conization]
Xin-er Zhu1, Yan Feng, Yun-feng Fu
1Zhejiang, Fuyang Women's Hospital, 311400, China.
Objective:
To evaluate the prevalence and influencing factors of residual disease in women with stage I a1 squamous cervical carcinoma after conization.
Methods:
The medical records and histopathologic slides of 83 women diagnosed with stage I a1 squamous cervical carcinoma after cervical conization undergoing subsequent hysterectomy at our hospital between January 2003 and December 2007 were reviewed. The correlations between the presence of residual lesions and clinicopathological features were analyzed.
Results:
Among them, 31 (37.3%) had residual disease in hysterectomy specimens, including CIN1 (n = 5), CIN2-3 (n = 10), microinvasive carcinoma (n = 11) and invasive carcinoma (n = 5). In univariate analysis, menopause, procedure of conization, and status of cone margins were associated with the prevalence of residual disease in stage I a1 cervical carcinoma after conization. However, Logistic regression analysis revealed status of cone margins as an independent risk factor for residual disease in stage I a1 cervical carcinoma after conization.
Conclusion:
Status of cone margins is an independent risk factor for residual disease in stage I a1 cervical carcinoma after conization. Further treatment should be performed in patients with positive or nearing cone margins.
