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Related Concept Videos

Jaundice01:25

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...

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Related Experiment Video

Updated: May 11, 2026

An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products
14:54

An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products

Published on: October 20, 2018

How to use: transcutaneous bilirubinometry.

Matthew C O'Connor1, Meredith A Lease, Bonny L Whalen

  • 1Department of Pediatrics, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.

Archives of Disease in Childhood. Education and Practice Edition
|May 11, 2013
PubMed
Summary

Transcutaneous bilirubinometry (TcB) offers a non-invasive method to assess neonatal jaundice, reducing the need for blood draws. While effective for infants over 35 weeks gestation, accuracy decreases at higher bilirubin levels.

Keywords:
JaundicePaediatric Practice

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Last Updated: May 11, 2026

An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products
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Published on: January 4, 2016

Area of Science:

  • Neonatal Medicine
  • Medical Device Technology

Background:

  • Neonatal jaundice is common, necessitating bilirubin level assessment.
  • Total serum bilirubin (TSB) is the standard diagnostic method.
  • Transcutaneous bilirubinometry (TcB) offers a non-invasive alternative.

Purpose of the Study:

  • To evaluate the clinical utility and limitations of TcB in assessing neonatal jaundice.
  • To compare TcB with TSB in infants greater than 35 weeks gestation.

Main Methods:

  • Review of existing studies validating TcB against TSB.
  • Analysis of TcB's performance in identifying hyperbilirubinemia risk.
  • Assessment of TcB's advantages and limitations in clinical practice.

Main Results:

  • TcB reliably identifies infants at risk for severe hyperbilirubinemia (>35 weeks gestation).
  • TcB can decrease the number of TSB measurements required.
  • TcB accuracy diminishes at higher bilirubin levels.

Conclusions:

  • TcB is a valuable tool for managing neonatal jaundice, offering convenience and reducing invasive procedures.
  • Paediatric providers must be aware of TcB's limitations, including accuracy at high levels and lack of validated nomograms.
  • Further research is needed on TcB use during phototherapy.