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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Severe aortic arch calcification depicted on chest radiography strongly suggests coronary artery calcification
Peter Bannas1, Caroline Jung, Philipp Blanke
1Department of Diagnostic and Interventional Radiology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany, p.bannas@uke.de.
Insights
Semi-quantitative grading of aortic arch calcifications (AAC) on chest X-rays is reliable and correlates with coronary artery calcium (CAC) scores. Severe AAC on radiography suggests significant coronary artery calcification, aiding in risk assessment.
Area of Science:
- Radiology
- Cardiovascular Imaging
- Diagnostic Accuracy
Background:
- Aortic arch calcifications (AAC) are visible on chest radiography.
- Coronary artery calcium (CAC) scoring via CT is a standard for cardiovascular risk assessment.
- The relationship between AAC on radiography and CAC scores needs further clarification.
Purpose of the Study:
- To evaluate the association between aortic arch calcifications (AAC) on chest radiography and coronary artery calcium (CAC) scores determined by CT.
- To assess the reliability and diagnostic performance of semi-quantitative AAC grading on chest radiography.
Main Methods:
- Retrospective analysis of 128 patients who underwent both chest radiography and CT CAC scoring.
- Independent blinded evaluation of AAC extent on chest radiography using a semi-quantitative four-point scale.
- Assessment of intra- and interobserver agreement using weighted kappa statistics and correlation with CAC scores.
Main Results:
- Excellent intraobserver (κ=0.82) and good interobserver (κ=0.75) agreement for AAC grading.
- Moderate agreement (κ=0.46) between AAC grades and CAC scores with a significant linear trend (P<0.0001).
- AAC grade cutoff (0-2 vs. 3) showed 38.6% sensitivity and 96.4% specificity for CAC scores >400.
Conclusions:
- Semi-quantitative AAC grading on chest radiography is a reliable method.
- AAC grading on chest radiography is positively associated with CAC scores.
- Severe AAC on chest radiography strongly suggests significant coronary artery calcification, warranting reporting in radiological reports.
Objective:
To evaluate the association between aortic arch calcifications (AAC) on chest radiography and coronary artery calcium (CAC) score determined by CT.
Methods:
A total of 128 patients (75 men; 69.3 ± 14.7 years) who underwent chest radiography and CAC scoring at CT were included in this retrospective analysis. The extent of AAC on chest radiography was evaluated independently by two blinded observers using a semi-quantitative four-point scale (0-3). Intra- and interobserver agreement was assessed by weighted ĸ statistics. Amount of AAC determined on radiography was correlated with CAC and ROC analyses performed to characterise the diagnostic performance of AAC grading.
Results:
Excellent intraobserver (ĸ = 0.82) and good interobserver (ĸ = 0.75) agreement of AAC grading was noted. Moderate agreement (ĸ = 0.46, 95 % CI 0.36-0.56) with a linear trend (P < 0.0001) between AAC grades and CAC scores was found. Cut-off between AAC grades 0-2 and 3 had a sensitivity of 38.6 %, specificity of 96.4 %, PPV of 85.0 %, NPV of 75.0 % and accuracy of 76.6 % for the correct identification of CAC scores greater than 400.
Conclusion:
Semi-quantitative AAC grading on chest radiography is reliable and positively associated with CAC scoring. We propose to report the extent of AAC in comprehensive radiological reports as "not present", "moderate" or "severe", as severe AAC strongly suggests coronary artery calcification.
Key Points:
• Semi-quantitative aortic arch calcification (AAC) grading on plain chest radiography appears reliable. • AAC grading is positively associated with CT coronary artery calcium scoring. • AAC grading has a high specificity for ruling out CAC scores greater than 400. • We propose the reporting of the extent of AAC grade in chest X-ray (CXR) reports.
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