Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.3K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.3K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

746
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
746
What is the Immune System?01:38

What is the Immune System?

127.2K
Overview
127.2K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

602
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
602
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K
Multiple Allele Traits01:49

Multiple Allele Traits

38.0K
The Concept of Multiple Allelism
38.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Aging, peripheral inflammation, and neurodegeneration.

Frontiers in aging neuroscience·2024
Same author

Prevalence and Impact of Cerebral Microbleeds on Clinical and Safety Outcomes in Acute Ischaemic Stroke Patients Receiving Reperfusion Therapy: A Systematic Review and Meta-Analysis.

Biomedicines·2023
Same author

Nervous system-related tropism of SARS-CoV-2 and autoimmunity in COVID-19 infection.

European journal of immunology·2023
Same author

Prospective analyses of alertness, sleep, and fitness to drive one year after de novo multiple sclerosis diagnosis.

Multiple sclerosis and related disorders·2023
Same author

Editorial: Insights in multiple sclerosis and neuroimmunology: 2021.

Frontiers in neurology·2023
Same author

Editorial: Telemedicine during and beyond COVID-19, volume II.

Frontiers in public health·2022

Related Experiment Video

Updated: Jan 26, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.0K

The immune pathogenesis of multiple sclerosis.

Robert Weissert1

  • 1Department of Neurology, University of Regensburg, Universitaetsstrasse 84, 93053 Regensburg, Germany. robert.weissert@ukr.de

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on Neuroimmune Pharmacology
|May 11, 2013
PubMed
Summary

Multiple sclerosis (MS) involves immune system damage to the central nervous system (CNS). Understanding diverse immune mechanisms and systemic factors is crucial for developing curative therapies for MS.

More Related Videos

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.1K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.7K

Related Experiment Videos

Last Updated: Jan 26, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.0K
A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
08:18

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS

Published on: December 26, 2015

18.1K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.7K

Area of Science:

  • Neuroimmunology
  • Autoimmune Diseases
  • Central Nervous System (CNS) Disorders

Background:

  • Multiple sclerosis (MS) is an autoimmune CNS disease damaging oligodendrocytes and neurons, impairing nerve conduction.
  • Immune cells including CD4+ T cells, CD8+ T cells, NK cells, B cells, and microglia contribute to MS pathology.
  • MS heterogeneity suggests varied immune mechanisms, with current treatments inadequately addressing neuronal and astrocytic signaling contributing to disease progression.

Purpose of the Study:

  • To explore the complex immune mechanisms underlying multiple sclerosis (MS).
  • To investigate the role of systemic immunity (gut and lung) and genetic factors (HLA class II) in MS.
  • To identify novel antigenic targets beyond myelin proteins, including astrocytic and neuronal proteins, in MS pathology.

Main Methods:

  • Review of current understanding of immune cell involvement in MS.
  • Analysis of genetic associations, particularly HLA class II alleles like HLA-DR2b.
  • Examination of emerging evidence on systemic immune influences and novel autoantigens in MS.

Main Results:

  • MS involves a complex interplay of innate and adaptive immune responses affecting both white and grey matter.
  • Systemic immunity, particularly gut and lung immunity, and specific HLA class II alleles are implicated in MS.
  • The immune response in MS targets not only myelin proteins but also astrocytic and neuronal proteins.

Conclusions:

  • Further research into the diverse immune mechanisms and systemic factors is essential for understanding MS.
  • Identifying novel autoantigens is critical for developing targeted therapies.
  • A comprehensive understanding of MS pathogenesis is key to discovering curative treatments.