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Transcranial laser therapy and infarct volume.

Scott E Kasner¹, David Z Rose, Alexander Skokan

¹Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA. kasner@mail.med.upenn.edu

|May 11, 2013

Summary

Transcranial laser therapy (TLT) did not reduce infarct volume in acute ischemic stroke patients. This study found no significant benefit of TLT on overall or cortical infarct size in the subacute phase.

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Area of Science:

Neurology
Neurosurgery
Medical Imaging

Background:

Previous studies suggested potential benefits of transcranial laser therapy (TLT) for acute ischemic stroke.
Efficacy of TLT in reducing infarct volume, particularly cortical infarction, remained unconfirmed.

Purpose of the Study:

To evaluate the efficacy of TLT in reducing infarct volume in patients with acute ischemic stroke.
To assess TLT's impact on cortical infarction using quantitative and semiquantitative imaging methods.

Main Methods:

The NeuroThera Efficacy and Safety Trial-2 (NEST-2) was a randomized trial comparing TLT to sham treatment in acute ischemic stroke patients.
Infarct volumes were measured on CT/MRI scans on day 5; cortical involvement was assessed using modified Alberta Stroke Program Early CT Score (cASPECTS).

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Main Results:

No significant difference in total infarct volume, total ASPECTS, or cASPECTS was observed between TLT and sham groups.
Prespecified subgroups with indicators of cortical involvement also showed no treatment effect from TLT.

Conclusions:

Transcranial laser therapy (TLT) demonstrated no association with reduced overall or cortical infarct volume in the subacute phase of acute ischemic stroke.
The study did not confirm the potential benefits of TLT for acute ischemic stroke patients regarding infarct volume reduction.