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Published on: April 3, 2016
Late acute myopia syndrome induced by combination of sulfonamide drugs
Pavel Kozner1, Katarina Simonova, Bretislav Brozek
1*Department of Ophthalmology, Hospital Na Bulovce, Prague, Czech Republic †Department of Opthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA.
Abstract:
We present a case of late acute myopia syndrome following discontinuation of treatment with a combination of sulphonamide drugs. To the best of our knowledge, this is the first reported case with such a presentation, and suggests that the pathophysiological basis for the acute myopia syndrome is a rapid decrease in serum carbonic anhydrase inhibitors levels which may lead to a rebound increase in the production of aqueous humor and accumulation of suprachoroidal fluid. It is further postulated that there may be a cumulative effect of sulphonamide drug use on carbonic anhydrase activity in the ciliary body epithelium of susceptible individuals.
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