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Induction and Diagnosis of Tumors in Drosophila Imaginal Disc Epithelia
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Cyclin d1 expression in odontogenic cysts.

Nasim Taghavi1, Shirin Modabbernia, Alireza Akbarzadeh

  • 1Department of Oral and Maxillofacial Pathology, Shahid Beheshti University of Medical Science, Tehran, Iran. nasim.taghavi@yahoo.com

Turk Patoloji Dergisi
|May 11, 2013
PubMed
Summary

Cyclin D1 expression, a marker of cell proliferation, was higher in odontogenic keratocysts and glandular odontogenic cysts compared to other cyst types. This suggests cell cycle disturbances may contribute to the aggressiveness of these odontogenic cysts.

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Area of Science:

  • Oral Pathology
  • Oncology
  • Cell Biology

Background:

  • Odontogenic cysts are common jaw lesions with varying proliferative potential.
  • Cyclin D1 is a key regulator of the G1-S phase transition in the cell cycle and is often overexpressed in neoplastic and aggressive lesions.

Purpose of the Study:

  • To investigate and compare the expression of cyclin D1 in the epithelial lining of four common odontogenic cysts: odontogenic keratocyst, radicular cyst, dentigerous cyst, and glandular odontogenic cyst.
  • To evaluate if cyclin D1 expression levels correlate with the proliferative activity and potential aggressiveness of these cystic lesions.

Main Methods:

  • Immunohistochemical staining for cyclin D1 was performed on formalin-fixed, paraffin-embedded tissue sections from 23 odontogenic keratocysts, 20 dentigerous cysts, 20 radicular cysts, and 5 glandular odontogenic cysts.
  • Analysis focused on cyclin D1 expression, pattern, staining intensity, and localization within the epithelial lining of each cyst type.

Main Results:

  • A statistically significant difference in cyclin D1 expression was observed across the studied cyst groups (p < 0.001).
  • Cyclin D1 positive cells were predominantly located in the parabasal layer of odontogenic keratocysts and dentigerous cysts, a pattern significantly different from radicular and glandular odontogenic cysts (p < 0.01).
  • While odontogenic keratocysts showed stronger and more focal cyclin D1 staining intensity, this difference was not statistically significant among the groups.

Conclusions:

  • Higher cyclin D1 expression in the parabasal layer of odontogenic keratocysts and throughout the epithelium of glandular odontogenic cysts suggests a role in their proliferative activity.
  • These findings imply that disturbances in the G1-S cell cycle phase, indicated by cyclin D1 expression, may be associated with the aggressiveness of odontogenic keratocysts and glandular odontogenic cysts.
  • Further research into cell cycle regulation mechanisms is warranted for these specific odontogenic cyst types.