Related Experiment Video
Updated: May 11, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Day-to-day associations between subjective sleep and affect in regard to future depression in a female
Jessica A de Wild-Hartmann1, Marieke Wichers, Alex L van Bemmel
1Department of Psychiatry and Psychology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands. j.dewild-hartmann@maastrichtuniversity.nl
Background:
Poor sleep is a risk factor for depression, but little is known about the underlying mechanisms.
Aims:
Disentangling potential mechanisms by which sleep may be related to depression by zooming down to the 'micro-level' of within-person daily life patterns of subjective sleep and affect using the experience sampling method (ESM).
Method:
A population-based twin sample consisting of 553 women underwent a 5-day baseline ESM protocol assessing subjective sleep and affect together with four follow-up assessments of depression.
Results:
Sleep was associated with affect during the next day, especially positive affect. Daytime negative affect was not associated with subsequent night-time sleep. Baseline sleep predicted depressive symptoms across the follow-up period.
Conclusions:
The subtle, repetitive impact of sleep on affect on a daily basis, rather than the subtle repetitive impact of affect on sleep, may be one of the factors on the pathway to depression in women.
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