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Related Concept Videos

In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
Drug Dissolution: Requirements and Profile Comparison01:14

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...
Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...

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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

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Published on: July 27, 2022

In vitro dissolution study of atorvastatin binary solid dispersion.

Rahat Jahan1, Md Saiful Islam, Ahmad Tanwir

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.

Journal of Advanced Pharmaceutical Technology & Research
|May 11, 2013
PubMed
Summary
This summary is machine-generated.

This study enhanced atorvastatin solubility using solid dispersion with Poloxamer 188. The optimized formulations significantly improved drug dissolution rates, offering a promising delivery method.

Keywords:
Atorvastatinphysical mixingpoloxamer 188solid dispersionsolvent evaporation

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems

Background:

  • Atorvastatin (ATV) exhibits poor water solubility, limiting its bioavailability.
  • Solid dispersion (SD) is a technique to enhance the dissolution of poorly soluble drugs.

Purpose of the Study:

  • To improve the solubility and dissolution rate of atorvastatin (ATV) using the solid dispersion (SD) technique.
  • To investigate the role of Poloxamer 188 (POL188) as a hydrophilic carrier in ATV solid dispersions.

Main Methods:

  • Preparation of ATV-SD using physical mixing (PM) and solvent evaporation (SE) methods with varying ATV-POL188 ratios.
  • Characterization of solid-state properties using solubility studies, DSC, SEM, and FTIR.
  • Evaluation of drug release profiles and kinetic analysis using the Peppas-Korsmeyer model.

Main Results:

  • Solid-state characterization confirmed changes supporting improved solubility of ATV in SD formulations.
  • The percentage of POL188 significantly influenced the dissolution enhancement of ATV.
  • Optimized ratios (1:3 for PM, 3:0.5 for SE) demonstrated maximum ATV release enhancement (P < 0.05).
  • Drug release kinetics followed Fickian diffusion, best described by the Peppas-Korsmeyer model.

Conclusions:

  • Binary solid dispersions of ATV with POL188 prepared by PM and SE are effective for enhancing dissolution.
  • The study presents a simple and efficient method for developing improved atorvastatin formulations.
  • Poloxamer 188 is a suitable hydrophilic carrier for improving the dissolution of poorly soluble drugs like atorvastatin.