Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Development of the Limb Synovial Joints01:07

Development of the Limb Synovial Joints

Joints form during embryonic development in conjunction with the formation and growth of the associated bones. The embryonic tissue that gives rise to all bones, cartilage, and connective tissues of the body is called mesenchyme.
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical regulation of mesenchymal stem cell osteogenesis, bone matrix homoeostasis, and skeletal pathology.

Journal of tissue engineering·2026
Same author

Mechanical Phenotyping of MG63s Following Vibrational Stimulation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Mechanical and Electrical Phenotype of hiPSC-Cardiomyocytes on Fibronectin-Based Hydrogels.

Advanced healthcare materials·2025
Same author

Synthetic peptide hydrogels as a model of the bone marrow niche demonstrate efficacy of a combined CRISPR-CAR T-cell therapy for acute myeloid leukaemia.

Biomaterials·2025
Same author

Global metabolomics identifies new extracellular biomarkers of nanovibration-driven mesenchymal stem cells osteodifferentiation.

Biomaterials advances·2025
Same author

Placental endocrine function is controlled by maternal gut Bifidobacterium in germ-free mice.

Journal of translational medicine·2025
Same journal

Assessment of adaptive trabecular bone remodeling around a knee prosthesis stem using the Weinans model.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine·2026
Same journal

Biomechanical evaluation of a fully cortical-threaded screw for modified cortical bone trajectory fixation: Combined experimental and finite element study.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine·2026
Same journal

The influence of passive prosthetic knee joints on uneven compliant surface walking among transfemoral amputees under dual-task versus single-task conditions.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine·2026
Same journal

Bone remodelling around internal fracture fixations used for treating femoral neck fractures: A finite element analysis.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine·2026
Same journal

Design of a kinematic-compatible passive spinal exoskeleton with parallelepiped units.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine·2026
Same journal

The tipping point: Friction and thigh length influence imminent falls from a tilting ski lift chair.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Developments in stem cells: implications for future joint replacements.

Sarah E Maclaine1, Laura E McNamara, Alan J Bennett

  • 1Department of Orthopaedics, Southern General Hospital, 1345 Govan Road, Glasgow G514TF, UK. sarahmaclaine@fsmail.net

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
|May 11, 2013
PubMed
Summary
This summary is machine-generated.

Stem cell research shows promise for treating osteoarthritis and improving knee replacement outcomes. While a complete cure is distant, stem cells are expected to significantly impact future joint replacement therapies and implant design.

More Related Videos

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Related Experiment Videos

Last Updated: May 11, 2026

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
11:22

Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots

Published on: May 21, 2013

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect
05:23

Establishment and Evaluation of a Sheep Model of Full-thickness Osteochondral Defect

Published on: April 14, 2026

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Osteoarthritis is projected to cause a sevenfold increase in knee replacements in the US by 2030.
  • Current treatments focus on managing symptoms and eventual joint replacement.
  • Stem cell research offers potential for cartilage regeneration and osteoarthritis treatment.

Purpose of the Study:

  • To explore the impact of stem cell research on the future of knee replacement surgery.
  • To assess the potential of stem cells in preventing or treating osteoarthritis.
  • To examine advancements in implant technology influenced by stem cell research.

Main Methods:

  • Review of current stem cell applications in cartilage regeneration (expanded autologous chondrocytes, ex vivo expanded skeletal stem cells).
  • Analysis of ongoing research into mesenchymal stem cell injections for osteoarthritis.
  • Evaluation of stem cell contributions to biomaterial advancements in implant design.

Main Results:

  • Stem cells are being used to regenerate cartilage in osteochondral defects.
  • Mesenchymal stem cells are being investigated for osteoarthritis treatment, though quantitative data is limited.
  • Stem cell research is driving innovation in implant materials and design.

Conclusions:

  • Stem cells are expected to significantly impact future joint replacement, either through improved implant design or potential osteoarthritis cures.
  • Biologic articular replacements may emerge before the need for arthroplasty is eliminated.
  • Continued advancements in stem cell therapies and biomaterials will reshape orthopedic interventions.