Related Experiment Video
Updated: May 11, 2026

Pull-down of Calmodulin-binding Proteins
Published on: January 23, 2012
[The role of calmodulin in calcium-dependent signalling in excitable cells]
Elzbieta Rebas1, Tomasz Boczek, Antoni Kowalski
1Zakład Neurochemii Molekularnej, Katedra Biochemii Medycznej, Uniwersytet Medyczny w Łodzi, Łódź. elzbieta.rebas@umed.lodz.pl
Abstract:
Calmodulin (CaM) is a sensor protein, which takes part in calcium-dependent signaling, regulating processes like growth, differentiation, proliferation and motility. Calmodulin binds calcium ions during induction of intracellular signaling. It is also involved in silencing of calcium signal through activation of plasma membrane Ca(2+)-ATPase (directly) or SERCA pump (indirectly). Calmodulin may affect various channels, e.g. voltage gated calcium channels (VGCCs), transient receptor potential channels (TRPCs), NMDA receptors, calcium channels dependent on cyclic nucleotides or these located in endoplasmic reticulum (ryanodine receptors and all isoforms of IP3-dependent receptors).
Related Concept Videos
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Feedback Regulation of Calcium Concentration
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Amplifying Signals via Second Messengers
The Role of Ion Channels in Neuronal Computation
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Intracellular Signaling Cascades

